Smooth operation at high speed
Adopts a unique capping technology
High filling accuracy and large production capacity
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Glass Bottle IV Solution Production Line
AIPAK Engineering glass bottle IV infusion line (AIPAK-200GV) is composed of a bottle arranging machine, external washing machine, ultrasonic rough washing machine, vertical fine washing machine, depyrogenation tunnel, vacuum filling & stoppering machine, capping machine, lamp inspection machine and labeling machine. It completes bottle arranging, three-stage washing, depyrogenation, vacuum-drawing + nitrogen filling, T-shaped rubber stoppering, aluminum-cap crimping, lamp inspection and labeling — realizing automatic production of the whole process. Each machine can run standalone or as a linkage line. The line is mainly used for sterile glass bottle IV infusions (glucose, antibiotic, amino-acid, fat-emulsion) from 50 ml to 1000 ml at 60 bottles/min.
Glass bottle example:
Glass Bottle IV Solution Production Line Features:
- Complete 9-machine linkage line: arranging → external / rough / fine washing → depyrogenation → vacuum filling & stoppering → capping → lamp inspection → labeling.
- Three-stage washing (QJW6 external + QJBC12 ultrasonic rough + QCLJ48A vertical fine) with patented continuous-feed synchronous nozzle-tracking; degraded-water recycling reduces water consumption.
- Depyrogenation tunnel (ASMR1200): Class 100 laminar flow, Camfil H13 HEPA, F0 ≥ 1365 (endotoxin ≥ 3 log), bottle outlet < 30 °C, breakage < 0.01%; patented pressure-balance prevents refluence.
- Vacuum filling & stoppering (GCCY24/24B): 24 filling + 24 stoppering heads, constant-pressure tank + pneumatic diaphragm valve, vacuum + nitrogen filling (residual O₂ < 0.6%), accuracy ±1.5%, with CIP/SIP.
- T-shaped rubber stopper sealing; no-bottle-no-fill, no-bottle-no-stopper functions.
- Capping machine (AGL10): 10-head aluminum-cap crimping at 120–165 r/min, multi-block inlay for wear parts, under LAF.
- Lamp inspection (SDJ) for seal tightness, foreign matter and clarity; labeling (ANZ120) for 20–1000 ml round bottles.
- Staggered track connections and differential non-resistance conveying for smooth high-speed operation.
- Siemens S7-1200 PLC control; product-contact parts stainless steel; GMP / Chinese Pharmacopoeia compliant.
Glass Bottle IV Solution Production Line Technical Specification:
| Item | Specification |
| Line model | AIPAK-200GV |
| Bottle material | Glass infusion bottle (GB2639-90) |
| Bottle size | 50–1000 ml |
| Line speed | 60 bottles/min |
| Filling & stoppering | GCCY24/24B, 24 filling + 24 stoppering heads |
| Filling method | Vacuum-drawing + nitrogen (constant-pressure tank + pneumatic diaphragm valve, CIP/SIP) |
| Filling accuracy | ±1.5% |
| Residual oxygen | < 0.6% (50/100 ml) |
| Sealing | T-shaped rubber stopper + aluminum cap |
| Depyrogenation | Tunnel ASMR1200, F0 ≥ 1365, ≤ 350 °C, Class 100, Camfil H13 |
| Bottle outlet temp | < 30 °C |
| Breakage rate | < 0.01% |
| Capping | AGL10, 10 heads, 120–165 r/min, with LAF |
| Power supply | 380V 50Hz 3-phase |
| Control system | Siemens S7-1200 PLC + TP1200 HMI, Schneider, Yokogawa recorder |
| Compliance | GMP, Chinese Pharmacopoeia, CE |
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