Ampoule Filling Line
AIPAK ENGINEERING ampoule filling line includes washing, filling and sealing machine for open or closed ampoules to be produced, guaranteeing perfectly repeatable, perfectly washing, filling and sealing operations. The cost and time-efficient, high-capacity ampoule filling lines that AIPAK ENGINEERING offers will satisify the increasing demand for ampoule fillers. As filled with a measued quantity of liquid, ampoules are to be considered the best ever read-to-inject solutions as to be 100% tamper-proof. From low to high capacity production, all AIPAK ENGINEERING ensures gentle, hygenic and accurate filling, precise capping. With intelligent HMI, you will be able to set the whole production parameter and monitor the whole production process easily.
Ampoule Filling Line Details & Features
Vertical Ultrasonic Washing Machine
Inner wall cleaning uses three water and three air cycles, outer wall cleaning uses two water and two air cycles, with online pressure monitoring and recording of all cleaning media. The steam exhaust is equipped with a pneumatic check valve featuring an automatic backflow prevention mechanism and anti-drip design to prevent secondary contamination.
Advantages:
- Adopts European latest maintenance-free bottle washer with central rotary system.
- Automatic lifting protective cover, mist extraction outlet, dehumidification pipeline with condensate collection, and reserved sampling port.
Hot Air Circulation Sterilization Tunnel
The high-efficiency filter adopts a negative pressure sealing method, preventing particle introduction from sealing materials.In the cooling section, ambient air is used to cool the bottles uniformly, reducing the risk of bottle breakage.Equipped with an airflow equalizing device and air volume adjustment system to ensure uniform airflow within the chamber.
Advantages:
- The air pressure balancing control system ensures the pressure differentials between the preheating section and the bottle washing area, as well as between the cooling and preheating sections, ultimately maintaining a stable pressure gradient throughout the oven.
Ampoule Filling And Sealing Machine
The ampoule filling and sealing machine is driven by a three-phase asynchronous motor with variable frequency speed control. The filling mechanism is mechanical, utilizing a glass pump for metering. Filling is controlled by an electromagnetic or pneumatic actuator to enable "no bottle, no filling" operation. However, wear particles from the glass pump may enter the liquid. The bottle-infeed screw is driven by a gear speed-increasing system, with an electromagnetic clutch used to control its start and stop functions.
Advantages:
- A movable stopper is installed at the bottle inlet of the bottle-infeed screw. The stopper automatically swings left and right based on the pressure exerted by the bottles, preventing bottle breakage.
AIPAK ENGINEERING Ampoule Filling Line
High Quality 1-20ml Ampoule Filling Line
AIPAK ENGINEERING ampoule filling line is the perfect solution for the pharmaceutical industry. The whole production line is composed of ultrasonic bottle washing machine, dryer sterilizer and ampoule filling and sealing machine. It can complete spraying water, ultrasonic cleaning, air & water flushing of inner and outer wall of ampoule bottle, preheating, drying and sterilization, heat source removing, cooling, (nitrogen pre-filling), filling, (nitrogen post-filling), ampoule sealing and other complex functions, realizing automatic production of the whole process.
Advantages:
- Various sealing gas supply methods such as natural gas or hydrogen and oxygen gas
- Equipped with online monitoring system to monitor key factors that affect product quality
- High precision colored touch screen operation monitoring
How Will You Benefit From AIPAK ENGINEERING Ampoule Filling Line?
High-speed washing, sterilizing&filling system
AIPAK ENGINEERING ampoule filling line adopts the latest technology, achieving high-speed production efficiency of over 30,000–40,000 bottles per hour.
Precision temperature control system
AIPAK ENGINEERING ampoule filling line is equipped with an advanced temperature control system to ensure precise temperature regulation during the washing and sterilizing process, thereby enhancing product quality.
Intelligent fault diagnosis
Equipped with a built-in intelligent diagnostic system, AIPAK ENGINEERING ampoule filling line can monitor the operating status of the equipment in real time, quickly locate faults, and provide corresponding solutions.
Energy-saving&environment friendly design
Features energy-saving and environmentally friendly design, reducing energy consumption and minimizing wastewater and exhaust emissions during production, in compliance with green manufacturing standards.
Applications of Ampoule Filling Line
Pharmaceutical Industry
Used for filling injectable solutions, vaccines, antibiotics, and sterile water for injection. Support high-speed production&aseptic integrity.
Biotechnology & Laboratory Use
Ideal for small-batch or R&D production of biologics, peptides, and diagnostic reagents, ensuring consistent filling and minimal product waste.
Veterinary Medicine
Applied in filling animal health injectables, including vitamins, vaccines, and hormonal preparations, ensuring reliable sealing and long shelf life.
Cosmetic & Skincare Industry
Used for serums, ampoule-based skincare treatments, and active ingredients, delivering precise volumes and contamination-free packaging.
Nutraceuticals
Suitable for liquid supplements or herbal extracts that require sterile or light-sensitive packaging to maintain product potency and stability.
R&D and Pilot Production
Flexible configuration supports formulation testing, stability studies, and process validation, making it ideal for pilot-scale operations before full-scale manufacturing.
Download Our Latest Catelogue
Discover our full range of pharmaceutical liquid solutions. Download the catalogue to explore specifications, features, and applicatons.
- Full product range
- Detailed technical specs
- Industry applications
Ampoule Filling Line FAQ
1.What is an ampoule washing–drying–filling–sealing line?
It is a fully integrated production line designed to automatically wash, sterilize, fill, and seal ampoules under aseptic conditions, ensuring contamination-free processing.
2.How are ampoules cleaned before filling?
Ampoules pass through multi-stage washing stationsusing ultrasonic cleaning, purified water, and compressed airto remove particles and residues before sterilization.
3.What is the drying and sterilization process?
After washing, ampoules enter a hot air circulation sterilizing tunnel (up to 300°C)where they are sterilized and depyrogenatedto meet GMP and FDA aseptic standards.
4.How is liquid filling accuracy ensured?
The system uses high-precision peristaltic or piston pumps, with no-drip filling needlesand automatic volume adjustment to guarantee consistent dosage accuracy.
5.What types of ampoules can the line handle?
It supports open, closed, and self-standing ampoules, and can be adjusted for various sizes from 1ml to 10ml or more.
6.How are ampoules sealed after filling?
Sealing is done by gas flame melting, forming a hermetic tip sealthat ensures long-term product stability and prevents contamination.
7.Can the line be used for different products or formats?
Yes. With modular design and quick changeover, the line can handle multiple product types and ampoule formats with minimal downtime.
8.What are the cleanroom requirements for operation?
Typically, it operates under Class 100 (ISO 5) laminar airflowor in a Grade A/B cleanroom environment, ensuring aseptic conditions throughout the process.
9.How is validation and compliance ensured?
Each stage (washing, drying, filling, sealing) follows GMP, GAMP5, and FDAguidelines, with IQ/OQ/PQ documentationavailable for system validation.
10.What common maintenance does this line require?
Regular filter replacement, sensor calibration, lubrication, and flame nozzle cleaningare essential for consistent and compliant operation.
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