Your Pharmaceutical Blow-Fill-Seal (BFS) Machine Provider

Blowing, filling and sealing in one enclosed aseptic cycle — no bottle washing
LVP, SVP and single-dose oral liquid in PP / PE / HDPE
Turnkey scope available: water system + BFS + sterilization + inspection & packing

AIPAK Engineering BFS (Blow-Fill-Seal) Production Line

AIPAK Engineering BFS production line integrates container blowing, filling and sealing into one continuous, fully enclosed aseptic cycle. PP resin is extruded into an oval parison, thermoformed into a container under vacuum, precision-filled with sterilized solution, and the bottle mouth is sealed — all inside one machine, without a separate bottle-washing line and without operator contact with the product path.
Because forming, filling and sealing happen in one uninterrupted cycle, BFS removes the empty-container supply chain and sharply reduces the risk of cross-contamination. It offers strong aseptic stability, low production and operating cost, and is well suited to terminally sterilized and aseptic products in plastic packaging. Bottle formats run from small-volume ampoules up to 1,000 ml LVP bottles, with CIP/SIP capability and GB150-compliant pressure vessels.
Beyond the BFS machine itself, AIPAK Engineering can deliver the complete IV plant as a turnkey package — pharmaceutical water system (RO/EDI + WFI + pure steam), solution preparation, BFS filling, autoclave sterilization, and inspection & packing — under one contract, with a full IQ/OQ/PQ validation document set.

BFS (Blow-Fill-Seal) Production Line

Plastic Bottle BFS (Blow-Fill-Seal) Machine LVP (Large Volume Parenteral) Production Line

AIPAK Engineering plastic bottle BFS machine LVP production line integrates molding, filling and sealing under complete control, packaging solution into PP / HDPE / LDPE bottles from 500 ml to 1,000 ml. PP resin is extruded into a parison, thermoformed under vacuum, precision-filled with sterilized and filtered solution, and sealed in a controlled aseptic environment — in one cycle, meeting new GMP / FDA aseptic production requirements.

Blowing, filling and sealing in one enclosed aseptic cycle
Filling tolerance ±2%, wall-thickness tolerance ±0.1 mm, pass rate ≥99.8%
CIP/SIP capable, GB150 pressure vessel, product-contact 316L Ra ≤0.4 µm

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Plastic Ampoule BFS (Blow-Fill-Seal) Machine SVP (Small Volume Parenteral) Production Line

AIPAK Engineering plastic ampoule BFS machine SVP production line produces small-volume injections, eye drops, oral liquid, ear drops and similar products. It blows, fills and seals plastic ampoules within one machine under aseptic conditions, combining plastic ampoule forming, filling and sealing in one cycle. Output depends on filling quantity and mould cavity number.

One-cycle plastic ampoule forming, filling and sealing
High filling precision, color touch-screen operation monitoring
Compact structure, small footprint, low clean-room and energy cost

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BFS Machine Technical Specification

Item	Specification
Product type	Large-volume IV solution / SVP / oral liquid
Container material	PP / HDPE / LDPE
Container sizes	500 ml – 1,000 ml (SVP down to small-volume ampoule)
Output (single-layer mold)	2,000 bottles/h @ 1,000 ml (±10%, depends on format); higher with multi-cavity
Filling tolerance	±2%
Wall-thickness tolerance	±0.1 mm
Product pass rate	≥ 99.8%
Filled product	Max. temp. 35 °C, max. viscosity 1,000 mPa·s
Installed capacity	approx. 146 kW (operating approx. 80 kW)
Equipment dimensions	6.4 × 2.9 × 3.6 m (L×W×H)
Pressure vessel standard	GB150-2011
Product-contact surface	316L, Ra ≤ 0.4 µm (internal)
Key configuration	B&R PLC/servo, Parker hydraulics, GEMU valves, SMC/FESTO pneumatics