Meet with GMP standard
Filling Accuracy: ≤ ±1%
Compact and simple structure, small occupied area
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High Output Aseptic Liquid Vial Production Line
AIPAK Engineering liquid vial production line is composed of an ultrasonic bottle washing machine, depyrogenation tunnel sterilizer, filling & stoppering machine, and capping machine. It completes water spraying, ultrasonic cleaning, inner/outer wall flushing, preheating, drying and depyrogenation, cooling, vial unscrambling, filling, stopper unscrambling, stoppering, cap unscrambling and capping — realizing automatic production of the whole process. Each machine can be used separately or in a linkage line. The line is mainly used for liquid injections in glass vials, and can also be applied to antibiotics, bio-pharmaceuticals, chemical pharmaceuticals and blood products.
Vial liquid example:
Vial Automatic ultrasonic washing machine
Automatic washing machine consist of infeeding section, ultrasonic treatment section and final washing section, the containers are going through those sections for completion of the whole washing processing by Ultrasonic treatment, prewashing and final washing steps, the cleaning quality of the container washed meets any Pharmacopoeia and being able to validate.
Sterilizing Tunnel machine
Vial powder filling and stoppering machine
High Output Aseptic Liquid Vial Production Line Features:
1.The whole line meets new GMP requirements; cleaning effect meets the latest Pharmacopoeia standards.
2.Straight-line or wall-to-wall L-shaped layout to reduce cross-contamination risk and provide aseptic protection.
3.Applicable specification: 2–30 ml vial(as per user's requirement).
4.Production capacity: 50–600 bottles/min(by model, see specification table).
5.Number of filling heads: 4–24, selected according to output.
6.Filling accuracy: ≤ ±1% (according to drug characteristics).
7.Choice of filling pumps: glass pump, metal pump, peristaltic pump, ceramic pump.
8.Capping pass rate: ≥ 99.9%.
9.Compact, simple structure, small footprint.
10.Stable performance, easy and reliable operation.
11.High automation, few operators.
12.Filling in single row or double row.
13.Real-time display and printing of sterilization temperature (configurable).
14.Tunnel hot-air oven with even heat distribution and good depyrogenation effect.
15.Online sterilization of the tunnel cooling section (configurable).
16.Open-RABS isolation and Class 100 laminar flow (configurable).
17.No-vial-no-fill, no-stopper detection, no-vial-no-cap, and linkage stop functions.
18.Capping machine with dust/aluminum-scrap extraction (configurable).
19.Online monitoring of dust particles, planktonic bacteria, air velocity and pressure (configurable).
20.Full-line linkage control.
21.Fully automatic control: color touch-screen HMI, PLC control, automatic protection, frequency-conversion speed regulation.
22.Wide range of vial specifications, easy mould change.
23.Products customizable to actual customer demand.
24.Optional nitrogen pre-/post-filling for oxygen-sensitive products.
High Output Aseptic Liquid Vial Production Line Technical Specification:
| Model | APE4 | APE6 | APE8 | APE10 | APE12 | KGF20 | KGF24 |
| Applicable specifications | 2~30ml vial bottles | ||||||
| Filling heads | 4 | 6 | 8 | 10 | 12 | 20 | 24 |
| Production capacity | 50-100bts/min | 80-150bts/min | 100-200bts/min | 150-300bts/min | 200-400bts/min | 250-500bts/min | 300-600bts/min |
| Stoppling qualification rate | >=99% | ||||||
| Laminar air cleanliness | 100 grade | ||||||
| Vacuum pumping speed | 10m3/h | 30m3/h | 50m3/h | 60m3/h | 60m3/h | 100m3/h | 120m3/h |
| Power consumption | 5kw | ||||||
| Power supply | 380V 50Hz | ||||||
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