Sodium Hyaluronate Eye Drops: The Complete FAQ Guide In 2025

1.What do you understand by sodium hyaluronate eye drops?

Sodium Hyaluronate Eye Drops

Sodium hyaluronate eye drops is a sterile ocular preparation, used to keep the eyes lubricated and relieved. Do you know who is behind this soothing effect of eye drops? Its sodium hyaluronate, you can also say it as sodium salt of hyaluronic acid. This sodium hyaluronate possesses wonderful ability to preserve the moisture in the eyes and provides a calming effect, that’s the reason this formulation is regarded as ‘artificial tears’.

2.Do you have any idea about how does sodium hyaluronate eye drops work?

You read it before this drop is a substitution of tears. Do you recognize what importance tears hold?  This eye drops works in the same way as tear does, to provide different benefits to your eyes.

Keeps the eye wet and lubricated:

Keeps Eye Wet & Lubricated-Picture Courtesy: Heartland Eye Consultants

Sodium hyaluronate eye drops prove to be the effective way to keep the eye wet and lubricated. Are you wondering how this happens? The main ingredient is sodium hyaluronate, which is also present by nature in the body, owns the ability to retain water content. In this way, you find your eyes smooth and moist after using it.

Strengthens the tear film:

Strengthens The Tear Film

Tear film should be firm enough that the tear does not get evaporated quickly and must provide smooth effects to surface of eye. This eye drops take part in strengthening the tear film, so you will experience that eye remains wet for longer time and optical surface becomes soft.

Healing effect:

Sodium Hyaluronate Owns Healing Effects-Picture Courtesy: ZYRTEC

Sodium hyaluronate eye drops also carries the healing effects and upon applying, you will get to know that the wound present in your eye starts getting better. This formulation is used widely to treat corneal abrasion or wounds after surgery.

3.What are the conditions that can be treated by sodium hyaluronate eye drops?

You have got the better understanding of advantageous role of sodium hyaluronate eye drops. Now the question arises how this drop utilizes its beneficial role in correcting various eye conditions.

Dry eye disease:

Dry Eye Disease-Picture Courtesy: Cascade Eye & Skin Centers

Have you ever witnessed itchiness, redness, soreness and grittiness, all at once, in your eyes?  These are the symptoms that confirm you are having dry eye disease. This condition can be cured by using sodium hyaluronate eye drops. This eye drops not only moistens your eye but also gives a soothing effect.

Corneal lesion:

Corneal Lesion

Have you noticed that sometimes you injure your cornea by unnecessary rubbing of eyes? No need to worry for that as far as you have sodium hyaluronate eye drops. This eye drops has the wound healing effects and lesion can be easily treated by it.

Eye related allergic reactions:

Eye Becomes Sore Due To Excessive Light Exposure-Picture Courtesy: Legacy Eye Care

Have you seen someone suffering from soreness and irritation of eye? There could be many reasons for that, a contact lens, dust particle, light exposure or side effect of drug. Such condition is well treated by sodium hyaluronate eye drops as it provides emollient effect to the eye.

After surgery discomfort:

After Surgery Discomfort-Picture Courtesy: Discover Vision Centres

Do you know eye needs any soothing agent after surgery for proper healing? Like in the case of cataract surgery, in which you can use sodium hyaluronate eye drops for quick recovery and better wellbeing of your cornea and conjunctiva.

4.What is the composition of sodium Hyaluronate eye drops?

You are well briefed about the main component of this formulation, which is sodium hyaluronate but there are other ingredients, which are added to enhance the activity of active ingredient. In this topic, you get details about right composition of sodium hyaluronate ear drops and why these ingredients are included?

Components	Image
Active ingredient: sodium hyaluronate is the main ingredient of this formulation and it provides emollient and moisturizing effect.
Solvent: sterile water for injection is the solvent you can use to make this formulation.
Isotonicity enhancer: this ingredient makes the formulation less irritating and do you know how? By balancing the tonicity of product as body fluids are isotonic. Example: sodium chloride.
Lubricating agent: this agent is used to enhance the lubricating effect of product. Example: glycerin
Thickening agent: this ingredient is necessary to increase viscosity and water retaining ability of formulation. Example: sodium carboxy methylcellulose
Buffering agent: you include buffering agent to make formulation compatible to the eye surface. Example: boric acid
Preservative: you add this ingredient to keep the formulation stable during shelf life. This ingredient possesses ability to kill microbes. Example: benzalkonium chloride, purite

Few things you need to remember regarding composition of sodium hyaluronate eye drops that there are different brands and they have variant composition which is designed by manufacturers. Some products are available with no preservatives, do you know why? Long consumption of preservative containing products can cause different toxicities.

5.What kind of container is used to dispense sodium hyaluronate eye drops?

Do you know the container you select to dispense any drug has influence on its stability and efficacy?  Choosing the appropriate dispensing container is a part of flawless production and this container also helps you to deliver the medicine effectively.

Dropper bottle:

Dropper Bottle Is Used To Dispense Sodium Hyaluronate Eye Drops

Have you seen eye drop container? Isn’t it unique? There is reason for designing it in such way.  Dropper bottles are used to deliver eye drops and it is usually made from plastic that can be easily squeezed. It is comprised of a nozzle which is used to deliver formulation drop by drop and covered with cap to prevent any kind of contamination.

Ophthalmic squeezable dispenser:

Ophthalmic Squeezable Dispenser Used To Dispense Sodium Hyaluronate Eye Drops

Has this thought stuck your mind that how you dispense a preservative-free preparation? An innovation has been made in dropper bottle by adding tip-seal technology in it. Such container is called ophthalmic squeezable dispenser.

How Ophthalmic Squeezable Dispenser Works?

Do you want to know how it works? This container has cap which possesses the tip seal technology. When you squeeze the bottle, pressure is initiated in the container, which let the formulation to be delivered accurately by single drop formation at a time. When pressure gets down, drop formation stops.

In traditional dropper bottle, commonly you face a problem that 2-3 drops deliver together by applying pressure, which is solved by this new container. Secondly, cap of ophthalmic squeezable dispenser contains filter that nullifies the contamination chances and a multi-dose preservative-free formulation can be dispensed in it easily.

6.What can be the manufacturing process of sodium hyaluronate eye drops?

Manufacturing Of Sodium Hyaluronate Eye Drops

You are well-informed that sodium hyaluronate eye drops is made under aseptic conditions and reason is the need to keep it sterile so that there would be no fear of contamination. This preparation enters directly into the eyes, so manufacturing process must be efficient enough to produce a stable, sterile, non-irritant and potent product. You have to follow all the instructions set by good manufacturing practices (GMP) throughout the whole operation.

Steps of manufacturing process:	Information:
Procurement of ingredients: Picture Courtesy: Lifecore Biomedical	The process of manufacturing starts with procurement of ingredients you need to make this formulation. You have to make sure that all ingredients must possess best quality and source of supplying these ingredients must be trustworthy and documented. Sterile water for injection is sourced by passing water from water treatment system.
Mixing: Picture Courtesy: MXD Process	After selection of ingredients, you need to start the process of mixing. Pharmaceutical mixing tank is used for this purpose. Initially you dissolve sodium hyaluronate in water for injection. Keep temperature on cooling mode and stir the solution continuously to get better dissolved solution. Now you can add other ingredients and mix well to form a homogenous preparation.
Filtration: Picture Courtesy: MEGE Filtre	This preparation needs to be sterilized in a well manner. For this purpose, you can utilize sterile filters. These filters can kill microbes and also separate impurities from formulation.
Filling and capping: Picture Courtesy: Ipanda	Dropper bottles are introduced in filling and capping machine by the help of conveyor. You can observe that dropper bottles are correctly filled by using filling nozzle. After filling, these bottles are stoppered by placing nozzle at mouth of container. After stoppering, dropper bottles are moved to capping station. Cap is placed upon the nozzle of dropper to keep it safe from any sort of contamination.
Sterilization: Sterilization By Using Autoclave	After filling and capping, finalized product is being sterilized by using heat. Autoclave is conveniently utilized for the purpose of final sterilization to keep the product microbes-free.
Quality control: Testing pH-Picture Courtesy: News-Medical.Net	To maintain the quality of your product, you have to conduct some tests. You can check pH, osmolality, microbial content, particle presence, and purity of active ingredient or anything that has contribution in altering the quality of product.
Labeling & packaging: Labeled And Packaged Sodium Hyaluronate Eye Drops	Finally you label the dropper bottles with printed labels. These labels must contain important information about medicine, its storage, dose, expiry etc. After labeling, you pack the dropper bottle in a box to keep it safe during storage and distribution.

7.What is the main equipment used in manufacturing of sodium hyaluronate eye drops?

Do you agree with the fact that high quality manufacturing can never be possible without efficiently working equipment? The manufacturing of sodium hyaluronate eye drops demands for specially designed equipment, which can work flawlessly and yield a safe and sterile product.

Main equipment	Function
Water treatment system: AIPAK ENGINEERING Water Treatment System	Sterile water for injection is required of high grade purity. For this you can use water treatment system, it provides you pure sterile water for injection that also meets mandatory standards.
Pharmaceutical mixing tank:	Proper mixing of ingredients is essential for making this formulation effective. Pharmaceutical mixing tank is appropriate for this purpose. It has agitator and temperature controlled system that makes the mixing process quick and smooth and you get a homogenous preparation.
Sterile filter: Sterile Filter Used In Pharmaceutical Industry	Sterile filter takes part in maintaining the sterility of preparation. It works by using porous membrane that can retain microbes and undesirable particles and sterile solution is obtained in the end.
Eye drop filling and capping machine: AIPAK Ear Drop Filling And Capping Machine	Eye drop filling and capping machine performs the chief step of filling and capping the formulation precisely into the dropper bottle. This machine is fully automated and works seamlessly. It has three main stations that are filling station, stoppering station and capping station.
Autoclave: Aipak Autoclave	Autoclave is the finest mean to sterilize the furnished product. It is aimed to sterilize by using heat so that product gets free from microorganisms.
Labeling machine: Aipak Labeling Machine	Labeling machine for round bottle is used to label dropper bottle. Printed labels containing important information is applied horizontally around the dropper bottle.
Cartoning machine: Aipak Cartoning Machine	Cartoning machine is used to pack the dropper bottle into box for secondary packaging. This machine is easy to use and packs the containers in rapid speed.

8.Can you explain the right way to use sodium hyaluronate eye drops?

How To Use Sodium Hyaluronate Eye Drops?-Picture Courtesy: Stoney Creek Eye Care

Administering eye drops in proper way is quite tricky and that’s the reason, it is narrated in this topic in a well-defined manner.

First of all clean your hands with water or sanitize them to limit the chances of contamination.

After that shake your eye drop well so that ingredients can be mixed accurately and then open the cap of your eye drops.

Lean your head in backward position and by using one hand you can easily pull your lower eyelid to create a pocket.

By using other hand, you can easily introduce medicine into formed pocket by squeezing the dropper bottle.

After administering the medicine in eye, you can close your eyes and direct your face towards the floor. You can also press the side corner of your eye to prevent the flow of medicine in nose or throat.

Above tricks help you to deliver the sodium hyaluronate eye drops into the eyes safely & effectively.

Press Your Eye Corner To Stop The Medicine From Flowing Into Nose & Throat

9.Do you know the frequency of using sodium hyaluronate eye drops?

Frequency Of Using Sodium Hyaluronate Eye Drops-Picture Courtesy: Westmount Optometrists

Any drug that is administered according to right dose and route shows its dominant effects. This topic educates you about correct frequency of using sodium hyaluronate eye drops so that you can benefit with the knowledge and receive soothing and moisturizing effects of this eye drops.

You can administer two drops of sodium hyaluronate eye drops four times over. This is the standard recommended dose for a day but if you feel the need of medicine due to excessive irritation and dryness, you can use more frequently but after consulting your eye specialist.

10.Does sodium hyaluronate eye drops show some side effects?

Sodium hyaluronate eye drops is safe and convenient for you to use. But there is possibility that it can show some side effects. This topic is highlighting the commonly reported side effects to provide you awareness regarding this matter. When you will be well informed about the unwanted effects, you would deal the situation wisely.

Side effects	Picture
Irritation in eye can be felt by you upon introducing this eye drops.
You may experience burning sensation in eye.
Sometimes you can face blurring of vision.
You can also have the feeling of itching or swelling in the eyelids.

11.What can be the shelf life of sodium hyaluronate eye drops?

Shelf Life Of Sodium Hyaluronate Eye Drops

Sodium hyaluronate eye drops as being a sterile product, possesses two different shelf lives, now you are wondering how? The answer is very simple.

When this formulation is sealed, it can remain stable for around 18 months, keeping storage conditions fair during whole shelf life.

When you broke the seal, it can remain effective for utmost 30 days, after that it must be thrown away. Some formulations do not have preservatives in it; they have least shelf life of few days.

12.What storage conditions are considered for sodium hyaluronate eye drops?

Storage conditions hold a crucial role in keeping the formulation stable and potent. It does not matter either it’s a sterile product or non-sterile product. Here we will discuss the basic aspects that are needed to be catered to keep the sodium hyaluronate eye drops safe from degradation.

Suitable temperature to store the sodium hyaluronate eye drops is less than 25 ℃. High temperature can degrade that preparation and it may lost its potency.
This eye drops must be kept safe from light exposure.
Do not freeze the product. Just like high temperature, freezing can also make your eye drops useless.

13.Can you define the precautions that are necessary for administering sodium hyaluronate eye drops?

Precautions You Need To Know Before Using Sodium Hyaluronate Eye Drops

Eye is a delicate part of your body and you must be cautious about administering the right drug in your eyes. Here you get to know about precautions that are necessary for administering sodium hyaluronate eye drops.

The first thing you should know that the patient does not have the history of allergy to sodium hyaluronate.

You must clean your hands before touching the dropper bottle. You should not try to touch the tip of dropper, otherwise contamination could be possible.

You should administer this eye drop before any other eye drop, if you are on combination therapy.

You must see the expiration and recommendation of using it along with contact lens before introducing it in eye.

After opening the product, remember the date and discard it after 30 days. If it is preservative-free, throw it earlier as per manufacturer’s claim.

You must follow the proper method of introducing the medicine by the help of dropper bottle.

If you would experience some side effects, stop the administration of eye drops and discuss this problem with your consultant.

Conclusion:

Sodium hyaluronate eye drops works in place of natural tears and ensures to provide soothing, lubricating and moisturizing effects to your eyes. This formulation requires proper administration into the eye to show its prominent effects. Production of ear drops is carried out under aseptic environment with specially designed equipment in order to get a high quality sterile product. Are you still feeling the need to be more mindful about sodium hyaluronate ear drops? You can contact AIPAK ENGINEERING anytime!