Semaglutide Tablets Vs Injection

1.What is Semaglutide?

Semaglutide- Picture Courtesy: Mountcastle medical

Semaglutide is the drug which is mainly approved for treatment problems related to Type 2 diabetes. Before explaining the answer, you must know what’s going on during this phase. Type 2 diabetes or T2D is prevalent chronic health issues where your body is in constant hyperglycaemic phase. Therefore, with that you phase challenges like heart problems, brain related ailments, macrovascular as well as microvascular problems. So, your overall quality of life gets disturbs.

Understanding What’s Going Inside Your Body

Insulin And Glucagon Relationship- Picture Courtesy: Bioninja

What’s going on inside your body is, that your insulin can not secrete enough to meet with whatever food you take. In a normal person, when your blood sugar is high, insulin makes it low. When your blood sugar is low, glucagon makes it high. So, these hormones work to regulate your body balance and are secreted by pancreatic cells for example alpha cells for glucagon and beta cells responsible for insulin.

What Exactly Incretin Memetic Is?

Incretin Memetic Mechanism

After understanding a brief description of the insulin and glucagon relationship. Now, we’re telling exactly the purpose of using semaglutide. This medication is known as incretin memetic. This means, that incretin is a hormone produced by your gut when your tummy is with food, so it orders your body to secret insulin. Therefore, your blood sugar is regulated. So semaglutide is also incretin memetic glucagon-like peptide 1 that helps in insulin secretion and also makes you feel non-hungry and ensures delay of stomach emptying time. Consequently, you don’t feel hungry at all.

Ever Wonder What Are Available Semaglutide Formulations?

Formulation type- Picture courtesy: Drug Store News

Semaglutide is available in both formulation types such as oral and injectables. The class of incretin memetic that safely generates the optimum amount of insulin to equalize the balance of blood sugar level if it is too high. Both of these forms are composed of similar active pharmaceutical ingredients. However, there’s a huge debate for knowing why injectables are invented and prescribed if the oral formulation is available.

2.What are Semaglutide Tablets Vs Injection?

A semaglutide is the active pharmaceutical medicine required for the treatment of ailments like hyperglycemia and increased weight; therefore, its available formulations semaglutide tablets vs injection is a direct comparison of each other.  For this reason, we have highlighted a comparison analysis of semaglutide tablets and injections. Let’s find out now. 

Dosage Type

Dosage type- Picture Courtesy: Frobe Africa & Dr. V Medical Aesthetics

Semaglutide Tablet

Semaglutide tablets are designed which is most often suggested as a daily dose. This is mainly taken with a sip of water that is of course little sips that must not be more than 120 mL/ or more than half a glass of water. This is an oral solid dosage formulation where it is not recommended to either cut, chew, or split and requires extra administration care.

Semaglutide Injection

This is a liquid formulation that is prepared as a parenteral solution. It is already dispensed in a prefilled pen where a pre-determined concentration of the active solution is filled. You can inject the semaglutide pen one time in a week, whereas the tablet dosage is required daily. So, for that same day must be selected for your reminder but you can inject with the gap of 48 hours or more. Side by side, it concentration of dose can be determined by your doctor therefore you are not allowed to modulate your dose.

Route of Administration

MyDR. And Cleveland clinic

Semaglutide Tablet

The route of administration of semaglutide tablets is the oral route of administration. Undoubtedly, this is the most convenient and flexible for every individual without terrifying needles, pricking, and hurting yourself. Yes, its therapeutic action can be slower than considering the injectable.

Semaglutide Injection

This is injectable and you can use the subcutaneous route of administration. In this case, many of you may require support who can help in administering the injection. While many individuals prefer self-administering them. You probably prefer them when looking for an effective mode of therapy and fast results. The sharp bioavailability can be achieved with semaglutide injection without affecting other systems such as the digestive system.

Mechanism of action

Mechanism of action of semaglutide- Picture courtesy: News-Medical

The mechanism of action of semaglutide is basically based on four basic parameters. First it helps in the promotion of insulin section, controlling the glycated haemoglobin, reducing the glucagon secretion and also lowering the effects of feeling hungry. The injection and tablets of semaglutide works on the basis of same principle, however the mechanism of action of tablet and injection are different. We have described the following below:

Semaglutide Tablet

When you swallow an oral semaglutide tablet, you might think that it has initiated the work. In reality, it is not. Tablets will dissolve in your stomach as well as reach the intestine, but the active ingredients take time to absorb and produce their action in the blood circulatory system. Therefore, first, it reaches the blood then various organs, triggers receptors, and so on.

However, taking semaglutide tablets may bind to different receptors where some of which are specific while some may bind to non-target sites which is a kind of unwanted action. The bioavailability of the tablet is 0.8% which is examined as lesser than injection. However, the therapeutic action of semaglutide tablets is observed in a few weeks. For example, you can find positive effects for at least eight weeks and balance therapeutic response in 12 weeks. When comes to its half-life it is nearly one week.

Semaglutide Injection

The semaglutide injection works as a fast carrier of the active product. As injection helps in delivering the solution directly into your body system bypassing various digestive enzymes and organs like the stomach, and intestine; so, it helps offer greater bioavailability of active pharmaceutical ingredients.

As compared to tablets, the semaglutide injections are more readily bioavailable. Its recorded bioavailability is 89% which mainly reaches the peak concentration taking one to three days. Moreover, it takes one week to get out of your body. That’s why, your physician or doctor recommends its once-weekly dosage. In the first week, you will start observing changes in your physiology like changes in your hunger routine and some differences in weight.

Doses

Semaglutide Tablets

Semaglutide Tablets Available Strengths

Every prescriber starts the treatment of semaglutide tablets from lower concentrations. Once the patient starts feeling positive effects, the dose titration begins with increasing the strength of an active ingredient such as a semaglutide tablet.

That’s why it is available in three different concentrations. It is all about depending on your acceptability, your body’s response, and your tolerance rate that results in a positive response hence you can be either maintained or modulated with given doses. The available doses of semaglutide tablets are 3 mg, 7 mg, and 14 mg.

Semaglutide Injection

Semaglutide Injection Strengths- Picture Courtesy: BMI

As compared to semaglutide tablets, the injectables are designed with a lower strength of active ingredients. You have guessed right, the injectables are faster-acting than tablets and present high effectiveness in minimum doses. This is because it bypasses many physiological systems and enzymatic degradation therefore nothing can disturb its metabolism and active ingredients.

The possible available strength of semaglutide injection is 0.25 mg, 0.5 mg, 1 mg, and 2 mg. A minor dose such as 0.25 is considered as the starting dose which is mainly suggested when you’re starting the treatment. Therefore, your body must be capable of tolerating it. The standard dose of semaglutide is maintained at 0.5mg. If your body still not responding ideally then your physician may opt high dose of 1mg to achieve the target goal or 2mg for better control.

Benefits

Semaglutide Tablets

Semaglutide Tablets- Picture courtesy: Slim Body

The benefits of semaglutide tablets are:

No Fear of Pricking

If you’re scared of pricking yourself, don’t worry, the oral semaglutide tablet is ideal for this purpose. You can consume the tablet on an empty stomach just before 30 minutes of starting your food.

Flexible for Long Term Administration

Long-term use of medication can be convenient to you if it is in tablet formulation. Therefore semaglutide tablet is mostly preferred over injections among those individuals who have to take advantage for the long term. For example, weight management, and blood sugar levels.

Convenient for Busy People

Whether you’re at your workplace, traveling, or engaged with some commitments; the tablet semaglutide tablet is way more beneficial as you just need to grab and take it without dose management, requiring any support to inject, or any other hurdle.

Semaglutide Injection

Semaglutide injection- Picture courtesy: myethosspa

Extremely Potent and Effective

The semaglutide injection for the management of T2D or weight loss gives similar effects as tablets, but you will experience more pronounced effects than semaglutide tablet. This is all because of its high bioavailability and more consistent therapeutic profile than tablet form.

Required Just One Dose Per Week

When it comes to talking about its regular doses then semaglutide is beneficial for you. Here, you don’t need to administer per day injectables rather you have to administer semaglutide injection once a week. Due to its effects and half-life, it is suitable for giving you positive results for 4 to 5 days therefore its weekly dose is considered as safe and effective.

Stable therapeutic Profile

The primary and foremost benefit of semaglutide injection is that it offers you a stable therapeutic goal without stress for uncontrollable weight management or sugar treatment.

3.Semaglutide Tablets Vs Injection: How are they prepared?

The preparation of semaglutide tablets and injection are described below:

Semaglutide Tablets

Tablet Semaglutide Preparation- Picture courtesy: bmi doctors

The semaglutide tablet preparation is based on a series of steps involving with preparation of raw material, crushing, and sieving, followed by the granulation, drying, mixing, and ends with final compression. For this purpose, you need a large production line where all required steps are carried out smoothly.

So, once the semaglutide tablets are formed, further treatment includes steps such as coating that help protect your tablets and make them look appealing. Then, the tablets are packed either in bottles or blister packaging. So once the quality of the product and testing are approved, the final marketing and distribution is done.

Semaglutide Injection

Semaglutide Injection – Picture Courtesy: Ahara

Semaglutide injections are prepared in a highly sterilized environment. It includes with dissolving of active pharmaceutical ingredients in purified water with buffers and an optimized percentage of preservatives. The aseptic environment must be maintained using clean pharmaceutical rooms, and machines like water treatment plants, sterilization machines, high shear mixers, and aseptic prefilled injection machines or vial filling machines must be installed for the preparation of semaglutide injections.

In the last, the packaging is done in blister packs followed by cartons or boxes for secure movement and transportation.

4.What are the Potential Disadvantages of Semaglutide Tablets Vs Injection?

Semaglutide tablets vs injection, both formulations are absolutely beneficial for you. However, somehow, it can be associated with some disadvantages. These are not harmful or life-threatening but cause some frequent discomfort. For example:

Semaglutide Tablets

Semaglutide Tablets- Picture courtesy: Medshift Store

Intake Frequency

Semaglutide tablets are required to be taken with daily frequencies which has come to be one of the advantages over injectables which are only required once a week.

Low Bioavailability

Talking about semaglutide tablet that offers you lesser bioavailability. This is valid because it is formed by the number of excipients such as fillers, bulking agents, etc therefore affecting potency bioavailability. Moreover, it should not be given with food as it directly affects the bioavailability too.

Interaction with the GIT system

The semaglutide tablets when you take them orally, react with salivary glands enzymes, then upon reaching the stomach, various gastric enzymes interact with it and affect the potency. That’s why you should not eat the tablet during food. Moreover, the entire chain reaction negatively impacts its fast absorption.

Semaglutide Injection

Semaglutide Injection – Picture Courtesy: Healthcentral

Painful mode of administration

The most popular disadvantage of semaglutide injection is of course fear of pain. For many of you, when administrating the dose, get nervous and feel more pain due to anxiety. It directly makes the user uncomfortable.

Skin Reaction

In some cases, if you’re applying the same region of injection, it results in skin allergies and discomfort, for example: swelling, redness, continuous itching, etc. That’s why it is suggested to keep changing the site of the injection every week. For example, sometimes it should be your upper arm, thighs, and sometimes abdominal regions.

You will need supporters to inject

Many of you are unable to self-inject. Because many people get problems when seeing the injection and cannot be able to deal with it. Therefore, the whole treatment faces challenges and sometimes patients start skipping their medication protocols. In such cases, you will always need a supporting hand to help with easy administration.

5.Which Is the Best? Semaglutide Tablets Vs Injection.

Which Is The Best? Semaglutide Tablets Vs. Injection- Picture Courtesy: First For Women

Talking about which one is better or best, of course, no one answer fits all aspects. It all depends on situation-to- situation. In some cases, tablets win while in some cases you prefer injections.

Factors	Which is Best?	Description
Approachable	Semaglutide Tablet	The semaglutide tablets are way easier for your consumption and you can take them daily without worrying about hurting yourself. In case of injection, you will need to memorize the exact date of injection.
Fast effects	Semaglutide Injection	The semaglutide injection gives you faster results, therefore, it is a great solution for impatient individuals who are eager to get rapid therapeutic outcomes.
Bypassing GIT Enzymes	Semaglutide injection	You know that GIT secretions and enzymes affect the effectiveness of medication. In this case, semaglutide injection is a good choice which bypasses all these complications.
Risk of Infection	Semaglutide Tablet	If you’re worried about the risk of getting an infection or having allergic reactions, then a tablet is a good option as it is almost zero with oral consumption.

Conclusion

Semaglutide tablets vs injection- no matter the formulations- have provided you with excellent therapeutic effects for diabetes and controlling obesity. This is indeed the modern and Game-Changer medication in the modern world. In this article, we tried our best to highlight the important and basic points that distinguish the difference between semaglutide tablets and injections. Still, do you have questions? Why Not Contact Us? AIPAK ENGINEERING is the solution to have friendly communication and attain guidance related to pharmaceutical queries and machines. Explore our best solutions now.