Hand Foot And Mouth Disease Vaccine: The Complete FAQ Guide In 2025

1.What do you know about hand, foot and mouth disease vaccine?

Hand, Foot & Mouth Disease Vaccine Was Made By China In 2016 For The First Time-Picture Courtesy: PrimaKu

Hand, foot and mouth disease is a viral disease, which can be spread more often that’s why it is known as a contagious disease. This disease affects children of young age like five years old or less. Appearance of sores in mouth and rashes on hand and foot confirm the presence of disease. Do you feel the need of vaccine to stop this disease?

To relieve such painful symptoms, vaccine was produced in 2016 in China and now days you do not find any other treatment of this disease globally except the vaccine available in china to medicate hand, foot and mouth disease.

2.How does hand, foot and mouth disease vaccine work?

Enterovirus Type 71-Picture Courtesy: News-Medical.Net

Before getting acknowledged about how this vaccine works? You need to know what the main cause of this disease is, as vaccine is always made to target the cause of disease. Enteroviruses are the reason behind this disease especially enterovirus type 71 (EV71) and vaccine is produced against this EV71 virus. Let’s get to know about how it functions?

Do you sense what vaccine actually contains? It has inactive form of respective virus which is EV71. When you administer this vaccine, the immune system of the body gets exposed to this virus.

After that immune system learns it as external entity and creates antibodies to fight with the virus.

But what happens if virus will attack again? Immune system of body makes special cells which you can call memory cells, these cells have capability to remember the virus and when virus attacks again, body fight it by the help of antibodies.

Keep one thing in your mind that this vaccine works against EV71 virus only.

3.What disease symptoms can be prevented by hand, foot and mouth disease vaccine?

This topic is designed to educate you about the prominent symptoms of this contagious disease, which can be prevented by the help of hand, foot and mouth disease vaccine. This disease shows some particular conditions that ensures you about the presence of the ailment.

Symptoms	Image
Fever: You can observe rise in temperature of the body up to 101-103 Fahrenheit initially but most of the time, this fever is taken as common symptom.	Picture Courtesy: MedlinePlus
Inflammation of throat: You can see other condition as most commonly happened is inflammation of throat that causes problem is swallowing and talking too.
Mouth sores: The symptom that can mark the presence of the disease is mouth sores along with above conditions. Small red spots appear on tongue, gums and cheeks that are so aching. These spots turn into blisters too.	Picture Courtesy: Jupiter Kids Dentistry
Rashes: You can observe skin rashes on palm of hand, sole of feet and back side of body. This symptom is considered as main symptom of disease.	Picture Courtesy: Health
Other symptoms: Upon occurrence of disease, you can see other symptoms also get appear with main symptoms like fatigue, weakness, low appetite, anxiety, body ache etc.	Picture Courtesy: Connecticut Children’s

4.Are you aware of the privileges of hand, foot and mouth disease vaccine?

You have deeply understood the need of this vaccine for the prevention of painful symptoms of disease, but here you will get to know about the benefits of this rare vaccine.

Avoidance of hand, foot and mouth disease:

Avoidance Of Hand, Foot & Mouth Disease-Picture Courtesy: Heal Medical

This vaccine has significant role in prohibiting hand, foot and mouth disease and you know how necessary it is? This disease sometimes becomes so dreadful that it leads to fatality. This vaccine is the only available source to avoid the disease.

Minimizing spreadability of hand, foot and mouth disease:

Minimizing The Spreadability Of Hand, Foot And Mouth Disease-Picture Courtesy: Infectious Disease Advisor

This vaccine has vital role in limiting the spreadability of this disease as it is a contagious viral disease. Do you know how this minimization is made more effective?  Vaccines are administered in children of young age as a precautionary measure, which makes their immune system stronger against this virus.

Productive way to prevent disease:

Vaccine Is The Cost-Effective And Efficient Way To Control Hand, Foot & Mouth Disease-Picture Courtesy: University Of Oxford

Do you know what people do all over the world to avoid this disease? They just wash hands, avoid contact to infectious person etc. but these measures are not enough. It has been reported that the prevention made by taking vaccine is far more efficient and cost-effective way to control this disease.

5.Which route of administration is preferred for hand, foot and mouth disease vaccine?

Vaccine Is Given By IM In Vastus Lateralis Muscle-Picture Courtesy: The Royal’s Children Hospital

It is prior for you to get knowledge about what route your administration suits this vaccine. Hand, foot and mouth disease vaccine is given by intra-muscular route and do you understand why? Anti-muscular route of administration is considered as efficacious and safe. When you introduce the vaccine directly into the muscle, this enters blood quickly creating dominant effects and secondly muscles contain less vessels and nerves so you don’t worry about any damage to them.

Are you informed about the fact that muscle site is distinct for infants as compared to older children? It is preferable for infants like till 12 months, to inject the vaccine into vastus lateralis muscle which you find in anterolateral thigh. On the other hand, in case of older children you prefer to administer in deltoid muscle which you observe in upper arm.

In Children, Vaccine Is Administered By Deltoid Muscle-Picture Courtesy: The Royal’s Children Hospital

6.What can be the right dose of hand, foot and mouth disease vaccine?

Right Dose Of Hand, Foot And Mouth Disease Vaccine

Are you known to right dose of hand, foot and mouth disease? If not, this topic informs you about dose and age limit for giving this vaccine. You recognize it very well that this disease affects children commonly, so vaccine is given to children of age 6 months to 5 years old. The right dose of administering this vaccine is 0.5 ml in each dose, which is introduced in two doses. You will keep one month gap between two doses of vaccine.

7.What can be the ingredients of hand, foot and mouth disease vaccine?

Do you sense the necessity of being acknowledged about composition of any vaccine or drug? Such knowledge prevents you from getting allergic reactions from that vaccine or drug and you can use it in best possible way.

Hand, foot and mouth disease vaccine is a monovalent vaccine, do you understand the term monovalent? It means this vaccine can be effective against only one type of virus that is EV-71. Here you get learning about the common ingredients of hand, foot and mouth disease vaccine.

Ingredients	Image
Active ingredient: Inactive or de-activated form of virus EV-71: as you get the idea that this vaccine works against EV-71, so it contains in-active virus particles of EV-71.	Picture Courtesy: Iberdrola
Adjuvants: Aluminum hydroxide: this aluminum hydroxide is included in the form of gel as an adjuvant and do you know how it works? It facilitates the vaccine response by decreasing the release rate of vaccine, due to which you get immune response for longer period of time.
Saponin: this adjuvant is used to robust the immune response in the body so that vaccine effects get more dominant.	Picture Courtesy: ChemicalBook
Inactive ingredients: Stabilizers: stabilizer is counted as important part of vaccine and do you know why? This takes part in keeping vaccine stable and effective during the shelf life. Sucrose is usually used as stabilizer in vaccine.	Picture Courtesy: Levels Health
Preservatives: preservative takes part in saving formulation from microbial growth and provides stability. Here thimerosal is used for the same purpose.

8.Which container is suitable to dispense hand, foot and mouth disease vaccine?

Hand, Foot & Mouth Disease Vaccine Is Dispensed In Vials-Picture Courtesy: WHO

Do you realize that the choice of dispensing container has great effect on formulation? Yes, it has huge influence as it safeguards the potency and stability of the formulation. Hand, foot and mouth disease vaccine is commonly dispensed in vial, which is a small cylindrical shaped container that is made from borosilicate glass.

Do you know why? Glass vial is non-reactive with the formulation present inside and it proves to be the most convenient dispensing container to maintain the sterility and efficacy of vaccine. Sealing of vaccine vial is so reliable that there would be very few chances to have contamination in it. Vaccine is drawn in precise dose by the help of syringe that keeps you sure about the accuracy of dose.

9.What can be the process of producing hand, foot and mouth disease vaccine?

Production Of Hand, Foot And Mouth Disease Vaccine-Picture Courtesy: GoKunming

This topic educates you about how hand, foot and mouth vaccine gets prepared? It involves some important steps that require aseptic conditions and controlled environment to ensure safe and potent product. Good manufacturing practices (GMP) guidelines must always be accompanied during production.

Steps of producing vaccine:	Information
Cultivation of virus:	Have you thought from where you get the virus strain? The process of producing hand, foot and mouth disease vaccine starts with the selection of the strain of virus you want to use in vaccine. You learnt it before that this vaccine works for EV-71 virus, so you take this strain and cultivate it. For cultivation of virus, you can use petri dish, cell culture that support growth of virus. You can use bioreactor for providing favorable conditions for the growth of virus.
Inactivation of virus:	Have you wondered that virus strain can cause harm to human? It is the reason behind inactivating the virus strain so that we can nullify its harm causing ability and only obtain the antigenicity of virus. Mainly this antigenicity is integral to mimic the immune response. You can use chemicals like formaldehyde, beta-propiolactone for inactivating the virus strain.
Purification of virus:	What you suppose to do with the impurities this virus strain contains? It is so obvious, you purify the virus strain by utilizing available methods like centrifugation, ultrafiltration or chromatography.
Preparation of vaccine:	Now you get the inactivated virus strain which has complete antigenicity and that acts as active ingredient of vaccine. You can mix it with other ingredients like adjuvant, stabilizer and preservative by using mixing vessel.
Filling & sealing of vaccine:	You can use vial filling line for precise filling and sealing of vaccine in vials. Aseptic conditions are kept firm to avoid contamination. You can see process starts with washing and sterilizing of vials, water for injection is used to wash vials and UV radiation or heat is used for sterilization of vials. At filling station, you can observe accurate filling of vaccine in vials. It further proceeded to stoppering of vial by using rubber stopper. You come to know the sealing process of vial which ensures the safety of vaccine from microbial and environmental contaminants. Aluminum caps are placed over vials for sealing purpose.
Final sterilization of vaccine:	You can see like every pharmaceutical preparation, this vaccine product is also gets sterilized by using autoclave.
Quality control:	You must admit that quality assessment of vaccine product is integral to avoid the risk of contamination or poor quality. You can carry out different tests to make sure that the vaccine has high quality that matches the mandatory standards.
Labelling & packaging:	Before sending the product to the market, you must label and package it accurately. Vaccine vials are labeled with important information like product name, batch number, expiry date, dose etc. Vial labeling machine helps you to apply printed adhesive labels on vials. Packaging is far necessary to keep vaccine product firm during storage and transportation, vial cartoning machine provides authentic facility to package vaccine vials in boxes.

10.Which equipment is helpful in production of hand, foot and mouth disease vaccine?

Are you interested in learning about important equipment involved in production of hand, foot and mouth disease vaccine? It is essential to be informed about equipment too as production goes well because of efficiency of equipment. These equipment need to be complained with regulatory standards.

Equipment	Image
Water treatment system: Do you feel the need of water treatment system? It is required to purify the water. This system provides you high quality sterile water. Vaccine is a sterile product; it needs sterile water even for the washing of vials. So whenever water is used, it is taken by using water treatment system.	Aipak Water Treatment System
Bioreactors: Bioreactors are important part of production. Virus strain is cultivated in cell cultures that demand proper environment that can support viral growth. Bioreactor helps you to provide best conditions to grow virus strain.
Inactivation reaction tank: Do you understand the need of this tank? This tank is specially made to use for the purpose of inactivation of virus strain you get after cultivation. This strain is treated with different chemicals, maintaining suitable conditions inside the tank.	Picture Courtesy: BioProcess International
Centrifuges: Do you know how this virus strain gets purified? The most common way to purify it is centrifugation. This process supports the separation of viral strain from debris or unwanted particles present in it. Centrifuge is the instrument you can use to perform centrifugation.
Mixing vessel: Virus strain is mixed with other ingredients by the help of mixing vessel. Do you know what else properties this vessel contains? It provides you homogenous mixing, which is supported by the presence of stirrer. Temperature is controlled according to the formulation to promote consistent mixing of ingredients.
Vial filling line: Vial filling line is chief equipment used to fill and seal vials with vaccine. Do you know its important parts? This filling line is made by incorporating washing machine, sterilizing machine, filling and stoppering machine and capping machine.	Aipak Vial Filling Line
Autoclave: You find this instrument as basic way to sterilize the final products. Steam is used by autoclave to sterilize the products from pyrogens, endotoxins etc.	Aipak Autoclave
HPLC system: You can use this system to check the quality of vaccine. It is high performance liquid chromatography, which is considered as authentic measure to acquire the knowledge about product quality.
Vial labeling machine: You find vial labeling machine very useful for applying printed labels on vials. Pressure method or adhesive labels are used to place labels on vial.	Aipak Vial Labeling Machine
Vial cartoning machine: It is essential for you to use vial cartoning machine to package the vaccine in boxes for safe storage.	Aipak Vial Cartoning Machine

11.Does hand, foot and mouth disease vaccine cause side effects?

Yes, you can encounter some side effects after the administration of hand, foot and mouth disease vaccine. Here it becomes necessary to make you informed about side effects so that you can treat them on time with great efficiency.

Side effects	Image
Fever: You can often see that children develop fever after administering hand, foot and mouth disease vaccine.
Pain and swelling at site of injection: You can easily observe the redness, edema, and pain at the administration site.
Nausea, vomiting or diarrhea: These are the common side effects that you can often experience with vaccines or drugs.
Anxiety: Irritation can be seen after administration of vaccine.
Low appetite: You can find children with poor desire of eating after they got the shot of this vaccine.

12.What storage conditions are appropriate for hand, foot and mouth disease vaccine?

Storage Conditions For Hand, Foot And Mouth Disease Vaccine

Storage conditions need to be optimistic if you want a stable and effective product. Hand, foot and mouth disease vaccine also demands for some specific conditions for storage.

Refrigeration is crucial part of its storage, you always need refrigeration to store this vaccine between 2-8 C.

Always keep it in your mind that refrigeration does not mean freezing, as freezing can damage the composition of vaccine.

You must make it sure to store vaccine in its real packaging to avoid contamination.

13.When hand, foot and mouth disease vaccine gets expired?

Expiry Of Hand, Foot And Mouth Disease Vaccine

Hand, foot and mouth disease vaccine can get expired after 2 years of manufacturing but one important you must learn about it. Refrigeration is integral for storage of this vaccine and you need to store in on 4 C to keep it stable and potent, then it stays for two years as an effective vaccine product.

14.Are you informed about the precautionary measures of using hand, foot and mouth disease vaccine?

Precautions To Use Hand, Foot And Mouth Disease Vaccine-Picture Courtesy: Vietnam News

There are very fundamental precautionary measures that you are needed to practice while administering hand, foot and mouth disease vaccine.

• You must clean your hands or sanitize it. Use gloves before touching the instruments of administration. Avoid contact with infected individual.
• You must always use sterilize syringe and needle. Always look for expiration of vaccine before administration.
• You must be informed about patient’s allergies to avoid any trouble.
• You must inject the vaccine at relevant muscle site for profound effects and if you observe side effects, treat them immediately.
• This kind of viral infection becomes common before rainy season; you must spread awareness about the administration of vaccine.

Conclusion:

Hand, foot and mouth disease vaccine proves to be a breakthrough in prevention of hand, foot and mouth disease. This vaccine demands observance of good manufacturing practices (GMP) during production. You must always maintain storage conditions to keep vaccine sterile and potent. Are you looking for more information about hand, foot and mouth disease vaccine? You can contact AIPAK ENGINEERING for swift learning at any time.