Cat Triple Vaccine:The Complete FAQ Guide In 2025

1.What Is the Definition of Cat Triple Vaccine?

Cat Triple Vaccine - Sourced: EntirelyPets Pharmacy

The commonly heard cat triple vaccine is not called triad because it requires three consecutive injections. The cat triple vaccine generally refers to a three in one inactivated vaccine that can simultaneously prevent Feline Viral Rhinotracheitis, Feline Calicivirus, and Feline Panleukopenia (Feline Distemper), so it is also called as FVRV-FCV-FPV vaccine.

This vaccine can prevent three infectious diseases, and together with the rabies vaccine, it is the core vaccine that cats need to receive.

2.What Diseases Can Cat Triple Vaccine Protect Cats From?

Cats need to be vaccinated during the production process to prevent infectious diseases. The triple vaccine is the core vaccine that cats need to receive. Do you know which three diseases the cat triple vaccine mainly targets?

Cat plague

Cat Plague - Sourced: The Canberra Times

Cat plague, also known as feline panleukopenia, is an acute highly contagious disease of cats. There are many common symptoms of feline plague, which vary among different age groups. The most common symptoms are: lack of energy, loss of appetite, fever, stubborn vomiting, yellow green vomit, sticky secretions in the mouth, eyes, and nose, and sticky stool.

The most common onset of feline distemper is 3-5 months, which means that kittens are the most common and have the highest mortality rate. Cats under 1 year old are susceptible, with a mortality rate of 50% to 60%. The highest mortality rate for kittens under 5 months old can reach 80% to 90%.

Feline calicivirus infections

Feline Calicivirus Infections - Sourced: PetMD

Feline calicivirus disease is a common respiratory disease in cats. The main symptoms are: mental depression, fever, serous and mucous nasal discharge, conjunctivitis, stomatitis, tracheitis, bronchitis. Even after being cured, cats still carry the virus for a long time and can be transmitted to other healthy cats.

The mortality rate of feline calicivirus disease is not high, but it is still not low for kittens. The most frightening thing is its strong infectivity and long-term transmission of the virus.

Cat nose branch

Cat Nose Branch - Sourced: Scientific American

Cat nasal branch is an upper respiratory tract infection disease in cats, also known as feline infectious rhinotracheitis, which is a disease caused by feline rhinotracheitis herpesvirus. The main symptoms of cat nasal branches are quite common, the most common of which are: mental depression, loss of appetite, elevated body temperature, coughing, sneezing, tearing, and discharge from the eyes and nose.

The nasal branches of cats pose a great threat to young cats, with a mortality rate of up to 50% if left untreated after infection.

3.What Are the Benefits of Cat Triple Vaccine?

Why do we need to play cat triplets? This vaccine is mainly designed to prevent three infectious diseases and has the advantages of strong absorption.

Great preventive effect

Great Preventive Effect - Sourced: AOL

The main function of feline triple infection is to prevent infectious diseases among cats, namely feline distemper, feline cupping, and feline rhinoceros transmission. Among them, feline distemper is the most important. Infection with feline distemper is fatal for kittens, so hitting feline triple infection is of utmost importance for kittens.

Maintaining resistance

By injecting the cat triple vaccine, cats can improve their resistance to infectious diseases and avoid the occurrence of these diseases. At the same time, their risk of illness is greatly reduced.

Keeping healthy

Keeping Healthy - Sourced: World’s Best Cat Litter

As we all know, people are inevitably sick, and so are cats. Getting vaccinated with the triple vaccine can maintain the health of cats without affecting their families, and can better maintain a safe living environment.

4.What Packaging Types of Cat Triple Vaccine?

Do you know what packaging is available for the cat triple vaccine? Perhaps the most common one is vials, which actually come with pre filled syringe.

Vial

Vial - Sourced: Amazon

The cat triple vaccine is generally packaged in vials, which can be packaged in 1ml, 5ml, etc., depending on different needs. The vial is made of borosilicate glass material, which can withstand high temperature disinfection and has strong sealing, and will not be contaminated by external factors.

Pre filled syringe

Pre Filled Syringe - Sourced: IBSA

To be honest, some cat triple vaccines use pre filled syringes, but it is not common. The cat triple vaccines with pre filled syringes can accurately control the dosage of the drug, avoid inaccuracies during manual injection, and maximize the effectiveness of the cat triple vaccine. And there is no need to extract through injections, simplifying the vaccination process.

5.What Are the Production Process of Cat Triple Vaccine?

The cat triple vaccine is an inactivated vaccine, which has the advantages of short development cycle, relatively mature preparation process, non infectious toxicity, and high safety.

Step 1: Cell culture and collection

Obtained from three types of viruses and cultured, the viruses multiply extensively in these suitable environments. When the number of cells reaches a certain level, they are collected for subsequent processing.

Step 2: Filtering

In various viral fluids produced by cell culture, in addition to containing a large number of viral particles, there are also many impurities such as cell tissue fragments and metabolites. Before concentration, the virus solution must first be filtered to remove large particles and impurities, making it a semi transparent or transparent solution.

Step 3: Concentrate and purify

After initial filtration, there will still be a large amount of miscellaneous proteins and cell debris in the virus liquid. Therefore, it is necessary to concentrate and purify to remove impurities such as proteins and cell debris, enhance the induction of effective immune responses, reduce vaccine usage, and minimize adverse reactions.

Step 4: Inactivation

Using chemical agents or physical methods to treat purified virus suspensions, rendering the virus inactive while maintaining its immunogenicity. In order to maintain the inactivation process without impurities, the process should be kept completely closed.

Step 5: Mixing

After virus inactivation, other excipients can be added and mixed in a certain proportion to prepare vaccines. You should be sure to maintain uniformity when mixing.

Step 6: Filling

Qualified vaccines are filled into sterile bottles, usually penicillin bottles. Bottle washing and high-temperature disinfection are required, and finally precise filling is carried out through a filling type peristaltic pump to ensure the purity of each bottle of vaccine drug and the accuracy and consistency of the drug dosage.

Step 7: Lyophilization (for cat triple vaccine with lyophilized powder)

Some cat triple vaccines are in the form of lyophilized powder, so it is necessary to put the filled vaccine into a lyophilizer. During the lyophilized process, the growth of microorganisms and the action of enzymes cannot be carried out, so the original characteristics can be maintained.

Step 8: Sterilization

Before administering the cat triple vaccine, it should be placed in a autoclave for high-temperature sterilization. After sterilization, the autoclave will activate a rapid cooling function to cool the vaccine to a temperature suitable for administration.

Step 9: Labeling

As you know, there is relevant information on each vaccine. To facilitate product identification of cat triple vaccine, label each vial with basic information such as production date and product name.

Step 10: Packing

On the packaging line, the light inspection cameras take photos at different angles and under background light to ensure that there are no impurities mixed into the vial, the sealing plug position is accurate, and the vial body is not scratched. Then, the vaccine is packaged into the cartons.

6.What Machines Can be Used in the Production of Cat Triple Vaccine?

In the production process of cat triple vaccine, it is necessary to strictly maintain a sterile environment, and the production requires a lot of equipment.

Machine	Detail
Sterilizing filter Sterilizing Filter - Sourced: Tofflon Life Science	The sterilization filter can remove microorganisms from cultured bacteria, using two-stage deep filtration to remove impurities such as cell debris, and then filtering through a 0.2 µm filter to reduce microbial load.
Purification equipment Purification Equipment - Sourced: Imperial College London	Purification equipment generates centrifugal force through high-speed rotation, causing virus particles to settle and separate from cell debris, cell membranes, and other impurities. After virus particles are concentrated, a series of purification steps are usually required, such as density gradient centrifugation, gel filtration and affinity chromatography. The purpose of these steps is to further remove impurities and improve the purity and activity of virus particles.
Inactivation tank Inactivation Tank - Sourced: Pick Heaters	Based on the production characteristics of inactivated vaccines, the inactivation tank adopts a high-temperature resistant rock wool insulation layer and is equipped with a sanitary pressure gauge. The device is made of stainless steel material, which can provide a stable inactivation environment for vaccines.
Vacuum emulsifying mixer Vacuum emulsifying mixer	The vacuum emulsifying mixer uses a high-speed rotating cutting blade and rotor to evenly mix and sterilize viruses and other additives. This machine does not require manual mixing and can automatically complete mixing and emulsification. Modern vacuum emulsifiers can not only stir and mix, but also heat and cool, and adjust the speed and time of homogenization stirring, with a high degree of automation.
Cat triple vaccine pre filled syringe production line Cat Triple Vaccine Pre Filled Syringe Production Line	Cat triple vaccine pre filled syringe production line is an advanced production equipment mainly composed of syringes, needles, syringes, and sealing caps. The principle is to first fill the needle tube with medication, and then inject it into the drug bottle through the needle, avoiding the risk of drug contamination and cross infection.
Vial lyophilization powder injectable powder production line Vial Lyophilization Powder Injectable Powder Production Line	Vial lyophilization powder injectable powder production line is made of stainless steel, which is resistant to acid and alkali corrosion. It can conduct bottle washing, filling, and plugging. The entire production process is carried out in a sterile environment.
Lyophilizer Lyophilizer	To produce vaccines in freeze-dried powder form, a lyophilizer is required. The principle of a lyophilizer is to freeze and crystallize the solution vaccine into a solid state. This machine is equipped with CIP and SIP functions, which can control aseptic production and processing, ensuring that lyophilized cat triple vaccine is not contaminated.
Autoclave Autoclave	After the cat triple vaccine is filled into vials, further sterilization is required. The autoclave uses high temperature for sterilization and disinfection. After completion, the vials will be lowered to room temperature for later use.
Labeling machine Labeling Machine	The labeling machine is equipped with high-precision sensors and control systems, which can accurately monitor and control the position and tension of the labels, ensuring the accuracy of label adhesion. The label is labeled with product name, production date, serial number, and other information.
Cartoning machine Cartoning Machine	The cartoning machine packs the cat triple vaccine vials into cartons, and each vaccine comes with an instruction manual, and after packaging, it will be weighed online. Once the weight is found to be incorrect, such as missing instructions or push rods, it will be removed to provide an additional layer of protection for vaccine safety.

7.How Often Do Cats Need Cat Triple Vaccine?

How Often Do Cats Need Cat Triple Vaccine - Sourced: The Vets

Cat distemper, cat nasal branch, and cat cup-shaped diseases have strong infectivity and high mortality rates, especially cat distemper, which can cause a mortality rate of up to 90% in kittens after infection. Therefore, cats need to receive the triple vaccine.

First dose	8-9 weeks old
Second dose	3-4 weeks apart (approximately 12 weeks old)
Third dose	Around 16 weeks of age (strengthened immunity)

When cats reach adulthood, they also need to be vaccinated with cat triple vaccine, with an additional dose every 1-3 years (based on antibody testing or veterinary advice).

8.What Are the Side Effects of Cat Triple Vaccine?

Most cats do not experience serious adverse reactions after vaccination, and some minor adverse reactions are acceptable, but other side effects need to be taken seriously.

Depression

Depression - Sourced: Animal Wellness Magazine

After finishing, some cats may experience a lack of energy, such as drowsiness, loss of appetite, and lack of energy for 1-2 days, which are normal immune reactions that usually resolve on their own within three days.

Nephritis

Cat triple therapy is cultured with kidney cells. When it enters the cat’s body, the immune system may indiscriminately attack its own kidney cells, so cats with nephritis should not be attacked.

Allergy

Allergy - Sourced: Just Cats Clinic

Some substances in cat triple vaccines can cause allergic reactions in some cats. After vaccination, doctors will require them to stay in the hospital for half an hour for observation. Allergic reactions are usually asthma, cough, difficulty breathing, vomiting, diarrhea, bloody stools, and so on.

9.Can You Get Cat Triple Vaccine for Cats by Yourself?

The answer is yes, but it is not recommended to get cat triple vaccine for cats.

Not convenient for timely assistance

Finding reliable channels to purchase cat triple vaccines on your own can indeed be much cheaper than getting vaccinated at a pet hospital, but cats may experience allergic reactions after vaccination and can receive timely assistance at the hospital.

Cannot guarantee the legitimacy of vaccines

Cannot Guarantee the Legitimacy of Vaccines - Sourced: ibtekr.org

Moreover, the vaccine channels you purchase may not be legitimate, and during the logistics process, the cat triple vaccine may become ineffective due to certain reasons. It is recommended that you go to a legitimate hospital for injection.

Skilled personnel with injection experience should purchase cat triple vaccines themselves and administer them at home. It is important to ensure that the channels for purchasing vaccines are legitimate and can be transported via cold chain.

10.Can the Cat Triple Vaccine Be Administered Simultaneously With Other Vaccines?

Administer Cat Triple Vaccine - Sourced: Mount Pleasant Vet Clinics

Vaccination is essential for cats throughout their lives, and cats need to receive two types of vaccines: cat triple vaccine and rabies vaccine.

Cat triple vaccine cannot be administered simultaneously with other vaccines, especially rabies vaccine, because if there is a small probability of allergic reaction, it is impossible to distinguish which vaccine is causing it.

Therefore, other vaccines should be administered one month after receiving cat triple vaccine. When choosing vaccines, healthcare professionals should also do their homework and choose high-quality and effective vaccines.

11.What Issues Should Be Paid Attention To When Getting Cat Triple Vaccine?

In order to ensure that cats can smoothly absorb the vaccine and produce results, there are some things to pay attention to before and after injecting the cat triple vaccine.

(1)Before injection:

Keep healthy

Keep Healthy - Sourced: SunTech Medical

Be sure to get vaccinated while ensuring the cat’s physical health! It is not advisable to vaccinate cats for colds, gastrointestinal discomfort, and other conditions, as the consequences may be unimaginable and even lead to illness, blindness, and other illnesses in cats.

Avoiding special periods

When administering the cat triple vaccine, it is necessary to avoid the deworming period. If deworming is imminent, it is recommended to wait for at least 7 days before vaccination. In addition, kittens (under 2 months old) and pregnant cats should not be vaccinated.

(2)After injection:

Alternating cold and hot compress

If there is swelling after the injection, alternating cold and hot compress can be used, which generally does not cause pain and will disappear in about a week; But if the swelling does not subside or even enlarges, it may be a pathological tumor (which usually occurs with frequent injections), and timely resection and treatment are needed (therefore, it is recommended to hit the limbs) for cats.

Not taking a shower

Not Taking a Shower - Sourced: ADAMS

Do not give your cat a bath within a week after receiving the cat triple vaccine. Within a few days of receiving the vaccine, your resistance may weaken and you may experience stress. If you give your cat a bath, it is more likely to make it sick.

Not changing the environment

Do not take your cat to unfamiliar places. After getting vaccinated, you can provide a stable and comfortable environment for the cat to restore its immunity for one week.

12.How Long Does It Take for Cat Triple Vaccine To Build Immunity?

How Long Does It Take for Cat Triple Vaccine To Build Immunity - Sourced: Cats Only Veterinary Hospital

Do you know how long it takes for a vaccine to produce antibodies immediately after injection?

Generally, cats need to wait for 7-10 days to produce antibodies after being injected with cat triple therapy. So during the time from injection to antibody production, it is recommended to protect your cat and avoid contracting those three diseases during this period.

13.How to Store and Handle the Cat Triple Vaccine?

In order to maintain the activity of cat triple vaccine, it is necessary to store the vaccine in a suitable location to avoid losing its potency.

Temperature

Vaccines must be stored in the refrigerator to ensure their activity is not compromised. The temperature range should be strictly controlled between 2℃ and 8℃. If the temperature is too low or too high, the vaccine may lose its effectiveness.

Avoiding freezing

Avoiding Freezing - Sourced: Sciencing

For those that require long-term storage, cat triple vaccine should be stored in the freezer compartment (below 0 ℃) of the refrigerator, and inactivated vaccines should be stored in the refrigerator compartment. Freezing vaccines can cause them to lose their immune effect, so it is important to avoid placing them in a frozen environment.

Protected from light

To prevent light from affecting the stability of vaccines, they should be stored in a dark environment. Most vaccine packaging is opaque, but attention should still be paid to lighting conditions.

Paying attention to the expiration date

Paying Attention To The Expiration Date - Sourced: Hashmicro

The vaccine packaging is marked with an expiration date, which refers to the time when the vaccine can maintain its optimal efficacy under correct storage conditions. Cat triple vaccines used after their expiration date may not provide sufficient immune protection.

Conclusion

The cat triple vaccine is the core vaccine that cats need to receive, which is a vaccine for three infectious diseases. After reading this article, you must have gained a deeper understanding of the triple vaccine. If you have any further questions, please feel free to contact AIPAK ENGINEERING at any time.